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Researchers are actively exploring how this imbalance may contribute to inflammation, mitochondrial dysfunction, and age-related cellular changes over time

At the same time, STAT1 forms a complex with interferon regulatory factor 1 (IRF1), upregulates ACSL4, and promotes the integration of polyunsaturated fatty acids (such as arachidonic acid) into the phospholipids of tumor cell membranes, significantly increasing lipid peroxidation sensitivity (156, 219)

As a result, GLP-1 medications are FDA-approved specifically for chronic weight management, and are recommended by major medical organizations as part of a comprehensive weight loss program

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